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Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle
Allosteric effects of mutations, ligand binding, or post-translational modifications on protein function occur through changes to the protein’s shape, or conformation. In a cell, there are many copies of the same protein, all experiencing these perturbations in a dynamic fashion and fluctuating thro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664463/ https://www.ncbi.nlm.nih.gov/pubmed/26618518 http://dx.doi.org/10.1371/journal.pbio.1002306 |