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Biomarkers in phase I–II chemoprevention trials: lessons from the NCI experience
Early phase clinical trials are an essential component of chemopreventive drug development to identify signals of drug efficacy that can subsequently be explored definitively in phase III trials. Whereas phase I trials focus on safety and identification of optimal dose and schedule for cancer preven...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cancer Intelligence
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664504/ https://www.ncbi.nlm.nih.gov/pubmed/26635903 http://dx.doi.org/10.3332/ecancer.2015.599 |