In Vitro and In Vivo Comparison of Lymphocytes Transduced with a Human CD16 or with a Chimeric Antigen Receptor Reveals Potential Off-Target Interactions due to the IgG2 CH2-CH3 CAR-Spacer

The present work was designed to compare two mechanisms of cellular recognition based on Ab specificity: firstly, when the anti-HER2 mAb trastuzumab bridges target cells and cytotoxic lymphocytes armed with a Fc receptor (ADCC) and, secondly, when HER2 positive target cells are directly recognized b...

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Detalles Bibliográficos
Autores principales: Clémenceau, Béatrice, Valsesia-Wittmann, Sandrine, Jallas, Anne-Catherine, Vivien, Régine, Rousseau, Raphaël, Marabelle, Aurélien, Caux, Christophe, Vié, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664810/
https://www.ncbi.nlm.nih.gov/pubmed/26665156
http://dx.doi.org/10.1155/2015/482089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664810/
https://www.ncbi.nlm.nih.gov/pubmed/26665156
http://dx.doi.org/10.1155/2015/482089

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