Asymmetric protonation of EmrE

The small multidrug resistance transporter EmrE is a homodimer that uses energy provided by the proton motive force to drive the efflux of drug substrates. The pKa values of its “active-site” residues—glutamate 14 (Glu14) from each subunit—must be poised around physiological pH values to efficiently...

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Detalles Bibliográficos
Autores principales: Morrison, Emma A., Robinson, Anne E., Liu, Yongjia, Henzler-Wildman, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664823/
https://www.ncbi.nlm.nih.gov/pubmed/26573622
http://dx.doi.org/10.1085/jgp.201511404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664823/
https://www.ncbi.nlm.nih.gov/pubmed/26573622
http://dx.doi.org/10.1085/jgp.201511404

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