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Understanding the physiology of the asymptomatic diaphragm of the M1592V hyperkalemic periodic paralysis mouse

The diaphragm muscle of hyperkalemic periodic paralysis (HyperKPP) patients and of the M1592V HyperKPP mouse model rarely suffers from the myotonic and paralytic symptoms that occur in limb muscles. Enigmatically, HyperKPP diaphragm expresses the mutant NaV1.4 channel and, more importantly, has an a...

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Detalles Bibliográficos
Autores principales: Ammar, Tarek, Lin, Wei, Higgins, Amanda, Hayward, Lawrence J., Renaud, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664826/
https://www.ncbi.nlm.nih.gov/pubmed/26621775
http://dx.doi.org/10.1085/jgp.201511476