Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo

Blockade of CC chemokines is an attractive yet under utilized therapeutic strategy. We report the in vivo pharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivo efficacy of the protein can be interrogated using...

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Detalles Bibliográficos
Autores principales: McNeill, Eileen, Iqbal, Asif J., White, Gemma E., Patel, Jyoti, Greaves, David R., Channon, Keith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664965/
https://www.ncbi.nlm.nih.gov/pubmed/26620767
http://dx.doi.org/10.1038/srep17404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664965/
https://www.ncbi.nlm.nih.gov/pubmed/26620767
http://dx.doi.org/10.1038/srep17404

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