Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?

The genomes of RNA viruses are relatively small. To overcome the small-size limitation, RNA viruses assign distinct functions to the processed viral proteins and their precursors. This is exemplified by poliovirus 3CD protein. 3C protein is a protease and RNA-binding protein. 3D protein is an RNA-de...

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Detalles Bibliográficos
Autores principales: Moustafa, Ibrahim M., Gohara, David W., Uchida, Akira, Yennawar, Neela, Cameron, Craig E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664992/
https://www.ncbi.nlm.nih.gov/pubmed/26610545
http://dx.doi.org/10.3390/v7112919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664992/
https://www.ncbi.nlm.nih.gov/pubmed/26610545
http://dx.doi.org/10.3390/v7112919

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