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Replication timing is regulated by the number of MCMs loaded at origins

Replication timing is a crucial aspect of genome regulation that is strongly correlated with chromatin structure, gene expression, DNA repair, and genome evolution. Replication timing is determined by the timing of replication origin firing, which involves activation of MCM helicase complexes loaded...

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Detalles Bibliográficos
Autores principales: Das, Shankar P., Borrman, Tyler, Liu, Victor W.T., Yang, Scott C.-H., Bechhoefer, John, Rhind, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665009/
https://www.ncbi.nlm.nih.gov/pubmed/26359232
http://dx.doi.org/10.1101/gr.195305.115