Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models

Tumors are characterized by a rigid, highly cross-linked extracellular matrix (ECM), which impedes homogeneous drug distribution and potentially protects malignant cells from exposure to therapeutics. Lysyl oxidases are major contributors to tissue stiffness and the elevated expression of these enzy...

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Detalles Bibliográficos
Autores principales: Schütze, Friedrich, Röhrig, Florian, Vorlová, Sandra, Gätzner, Sabine, Kuhn, Anja, Ergün, Süleyman, Henke, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665164/
https://www.ncbi.nlm.nih.gov/pubmed/26620400
http://dx.doi.org/10.1038/srep17576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665164/
https://www.ncbi.nlm.nih.gov/pubmed/26620400
http://dx.doi.org/10.1038/srep17576

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