Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells

BACKGROUND: Two-hydroxyglutarate (2HG) is present at low concentrations in healthy mammalian cells as both an L and D enantiomer. Both the L and D enantiomers have been implicated in regulating cellular physiology by mechanisms that are only partially characterized. In multiple human cancers, the D...

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Detalles Bibliográficos
Autores principales: Gelman, Susan J., Mahieu, Nathaniel G., Cho, Kevin, Llufrio, Elizabeth M., Wencewicz, Timothy A., Patti, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665876/
https://www.ncbi.nlm.nih.gov/pubmed/26629338
http://dx.doi.org/10.1186/s40170-015-0139-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665876/
https://www.ncbi.nlm.nih.gov/pubmed/26629338
http://dx.doi.org/10.1186/s40170-015-0139-z

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