The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling

The tumor suppressor Adenomatous polyposis coli (APC) plays a key role in regulating the canonical Wnt signaling pathway as an essential component of the β-catenin destruction complex. C-terminal truncations of APC are strongly implicated in both sporadic and familial forms of colorectal cancer. How...

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Detalles Bibliográficos
Autores principales: Kunttas-Tatli, Ezgi, Von Kleeck, Ryan A., Greaves, Bradford D., Vinson, David, Roberts, David M., McCartney, Brooke M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666143/
https://www.ncbi.nlm.nih.gov/pubmed/26446838
http://dx.doi.org/10.1091/mbc.E15-07-0515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666143/
https://www.ncbi.nlm.nih.gov/pubmed/26446838
http://dx.doi.org/10.1091/mbc.E15-07-0515

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