Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth

DNA polymerase gamma (POLG) is essential for replication and repair of mitochondrial DNA (mtDNA). Mutations in POLG cause mtDNA instability and a diverse range of poorly understood human diseases. Here, we created a unique Polg animal model, by modifying polg within the critical and highly conserved...

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Detalles Bibliográficos
Autores principales: Rahn, Jennifer J., Bestman, Jennifer E., Stackley, Krista D., Chan, Sherine S.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666367/
https://www.ncbi.nlm.nih.gov/pubmed/26519465
http://dx.doi.org/10.1093/nar/gkv1139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666367/
https://www.ncbi.nlm.nih.gov/pubmed/26519465
http://dx.doi.org/10.1093/nar/gkv1139

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