Intergenic Alu exonisation facilitates the evolution of tissue-specific transcript ends

The 3′ untranslated regions (3′ UTRs) of transcripts serve as important hubs for posttranscriptional gene expression regulation. Here, we find that the exonisation of intergenic Alu elements introduced new terminal exons and polyadenylation sites during human genome evolution. While Alu exonisation...

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Detalles Bibliográficos
Autores principales: Tajnik, Mojca, Vigilante, Alessandra, Braun, Simon, Hänel, Heike, Luscombe, Nicholas M., Ule, Jernej, Zarnack, Kathi, König, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666398/
https://www.ncbi.nlm.nih.gov/pubmed/26400176
http://dx.doi.org/10.1093/nar/gkv956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666398/
https://www.ncbi.nlm.nih.gov/pubmed/26400176
http://dx.doi.org/10.1093/nar/gkv956

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