Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1

Simvastatin (SIM) is anti-inflammatory. We used low density lipoprotein receptor knockout (LDLR-/-) mice and human aortic smooth muscle cells (HASMCs) as model systems to study the effect of SIM on arterial calcification and to explore the potential mechanisms contributing to this protective effect....

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Detalles Bibliográficos
Autores principales: Lin, Chih-Pei, Huang, Po-Hsun, Lai, Chung Fang, Chen, Jaw-Wen, Lin, Shing-Jong, Chen, Jia-Shiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666466/
https://www.ncbi.nlm.nih.gov/pubmed/26625143
http://dx.doi.org/10.1371/journal.pone.0143686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666466/
https://www.ncbi.nlm.nih.gov/pubmed/26625143
http://dx.doi.org/10.1371/journal.pone.0143686

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