The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

The classical BCR-ABL-negative Myeloproliferative Neoplasms (MPN) are a group of heterogeneous haematological diseases characterized by constitutive JAK-STAT pathway activation. Targeted therapy with Ruxolitinib, a JAK1/2-specific inhibitor, achieves symptomatic improvement but does not eliminate th...

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Detalles Bibliográficos
Autores principales: Cardoso, Bruno A., Belo, Hélio, Barata, João T., Almeida, António M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666616/
https://www.ncbi.nlm.nih.gov/pubmed/26623653
http://dx.doi.org/10.1371/journal.pone.0143897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666616/
https://www.ncbi.nlm.nih.gov/pubmed/26623653
http://dx.doi.org/10.1371/journal.pone.0143897

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