Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto’s disease—the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the molecul...

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Detalles Bibliográficos
Autores principales: Le, Sarah N., Porebski, Benjamin T., McCoey, Julia, Fodor, James, Riley, Blake, Godlewska, Marlena, Góra, Monika, Czarnocka, Barbara, Banga, J Paul, Hoke, David E., Kass, Itamar, Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666655/
https://www.ncbi.nlm.nih.gov/pubmed/26623656
http://dx.doi.org/10.1371/journal.pone.0142615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666655/
https://www.ncbi.nlm.nih.gov/pubmed/26623656
http://dx.doi.org/10.1371/journal.pone.0142615

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