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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto’s disease—the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the molecul...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666655/ https://www.ncbi.nlm.nih.gov/pubmed/26623656 http://dx.doi.org/10.1371/journal.pone.0142615 |