Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondrial electron transport chain (ETC). However, the mec...

Descripción completa

Detalles Bibliográficos
Autores principales: Griss, Takla, Vincent, Emma E., Egnatchik, Robert, Chen, Jocelyn, Ma, Eric H., Faubert, Brandon, Viollet, Benoit, DeBerardinis, Ralph J., Jones, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666657/
https://www.ncbi.nlm.nih.gov/pubmed/26625127
http://dx.doi.org/10.1371/journal.pbio.1002309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666657/
https://www.ncbi.nlm.nih.gov/pubmed/26625127
http://dx.doi.org/10.1371/journal.pbio.1002309

Ejemplares similares