RNA catalyzes nuclear pre-mRNA splicing

In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a multi-megadalton machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, following the discovery of self-splicing group II intron RNAs, the snRNAs were hypothesized to catalyze splicing...

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Detalles Bibliográficos
Autores principales: Fica, Sebastian M., Tuttle, Nicole, Novak, Thaddeus, Li, Nan-Sheng, Lu, Jun, Koodathingal, Prakash, Dai, Qing, Staley, Jonathan P., Piccirilli, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666680/
https://www.ncbi.nlm.nih.gov/pubmed/24196718
http://dx.doi.org/10.1038/nature12734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666680/
https://www.ncbi.nlm.nih.gov/pubmed/24196718
http://dx.doi.org/10.1038/nature12734

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