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Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis

Introduction: In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins. The small GTPase RhoA orchestrates cytoskeleton formation, migration, a...

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Detalles Bibliográficos
Autores principales: Görtzen, Jan, Schierwagen, Robert, Bierwolf, Jeanette, Klein, Sabine, Uschner, Frank E., van der Ven, Peter F., Fürst, Dieter O., Strassburg, Christian P., Laleman, Wim, Pollok, Jörg-Matthias, Trebicka, Jonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667086/
https://www.ncbi.nlm.nih.gov/pubmed/26696895
http://dx.doi.org/10.3389/fphys.2015.00359