LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

Maintenance of mitochondrial protein homeostasis is critical for proper cellular function. Under normal conditions resident molecular chaperones and proteases maintain protein homeostasis within the organelle. Under conditions of stress however, misfolded proteins accumulate leading to the activatio...

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Detalles Bibliográficos
Autores principales: Bezawork-Geleta, Ayenachew, Brodie, Erica J., Dougan, David A., Truscott, Kaye N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667172/
https://www.ncbi.nlm.nih.gov/pubmed/26627475
http://dx.doi.org/10.1038/srep17397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667172/
https://www.ncbi.nlm.nih.gov/pubmed/26627475
http://dx.doi.org/10.1038/srep17397

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