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LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins
Maintenance of mitochondrial protein homeostasis is critical for proper cellular function. Under normal conditions resident molecular chaperones and proteases maintain protein homeostasis within the organelle. Under conditions of stress however, misfolded proteins accumulate leading to the activatio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667172/ https://www.ncbi.nlm.nih.gov/pubmed/26627475 http://dx.doi.org/10.1038/srep17397 |