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Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility
Pseudomonas aeruginosa is an opportunistic human pathogen for which new antimicrobial drug options are urgently sought. P. aeruginosa disulfide-bond protein A1 (PaDsbA1) plays a pivotal role in catalyzing the oxidative folding of multiple virulence proteins and as such holds great promise as a drug...
Autores principales: | McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667283/ https://www.ncbi.nlm.nih.gov/pubmed/26627647 http://dx.doi.org/10.1107/S1399004715018519 |
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