NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine

Interferon gamma (IFNγ)-producing CD8(+) T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8(+) T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augme...

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Detalles Bibliográficos
Autores principales: Bai, Aiping, Moss, Alan, Rothweiler, Sonja, Serena Longhi, Maria, Wu, Yan, Junger, Wolfgang G., Robson, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667632/
https://www.ncbi.nlm.nih.gov/pubmed/26549640
http://dx.doi.org/10.1038/ncomms9819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667632/
https://www.ncbi.nlm.nih.gov/pubmed/26549640
http://dx.doi.org/10.1038/ncomms9819

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