DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially lead to infertility and developmental disorders. However, there is little known about the response of oocytes to DNA damage. Here we find that oocytes with DNA damage arrest at metaphase of the first meiosis (MI). T...

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Detalles Bibliográficos
Autores principales: Marangos, Petros, Stevense, Michelle, Niaka, Konstantina, Lagoudaki, Michaela, Nabti, Ibtissem, Jessberger, Rolf, Carroll, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667640/
https://www.ncbi.nlm.nih.gov/pubmed/26522734
http://dx.doi.org/10.1038/ncomms9706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667640/
https://www.ncbi.nlm.nih.gov/pubmed/26522734
http://dx.doi.org/10.1038/ncomms9706

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