Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition

Understanding the relationship between protein sequence and molecular recognition selectivity remains a major challenge. The antibody fragment scFv1F4 recognizes with sub nM affinity a decapeptide (sequence (6)TAMFQDPQER(15)) derived from the N-terminal end of human papilloma virus E6 oncoprotein. U...

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Detalles Bibliográficos
Autores principales: Nominé, Yves, Choulier, Laurence, Travé, Gilles, Vernet, Thierry, Altschuh, Danièle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667898/
https://www.ncbi.nlm.nih.gov/pubmed/26629896
http://dx.doi.org/10.1371/journal.pone.0143374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667898/
https://www.ncbi.nlm.nih.gov/pubmed/26629896
http://dx.doi.org/10.1371/journal.pone.0143374

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