Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women’s Cancers

We introduce a novel per-gene measure of intra-gene DNA methylation variability (IGV) based on the Illumina Infinium HumanMethylation450 platform, which is prognostic independently of well-known predictors of clinical outcome. Using IGV, we derive a robust gene-panel prognostic signature for ovarian...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartlett, Thomas E., Jones, Allison, Goode, Ellen L., Fridley, Brooke L., Cunningham, Julie M., Berns, Els M. J. J., Wik, Elisabeth, Salvesen, Helga B., Davidson, Ben, Trope, Claes G., Lambrechts, Sandrina, Vergote, Ignace, Widschwendter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667934/
https://www.ncbi.nlm.nih.gov/pubmed/26629914
http://dx.doi.org/10.1371/journal.pone.0143178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667934/
https://www.ncbi.nlm.nih.gov/pubmed/26629914
http://dx.doi.org/10.1371/journal.pone.0143178

Ejemplares similares