Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding

A sequence of complex conformational changes is required for insulin to bind to the insulin receptor. Recent experimental evidence points to the B chain C-terminal (BC-CT) as the location of these changes in insulin. Here, we present molecular dynamics simulations of insulin that reveal new insights...

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Detalles Bibliográficos
Autores principales: Papaioannou, Anastasios, Kuyucak, Serdar, Kuncic, Zdenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668001/
https://www.ncbi.nlm.nih.gov/pubmed/26629689
http://dx.doi.org/10.1371/journal.pone.0144058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668001/
https://www.ncbi.nlm.nih.gov/pubmed/26629689
http://dx.doi.org/10.1371/journal.pone.0144058

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