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Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding

A sequence of complex conformational changes is required for insulin to bind to the insulin receptor. Recent experimental evidence points to the B chain C-terminal (BC-CT) as the location of these changes in insulin. Here, we present molecular dynamics simulations of insulin that reveal new insights...

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Detalles Bibliográficos
Autores principales:	Papaioannou, Anastasios, Kuyucak, Serdar, Kuncic, Zdenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668001/ https://www.ncbi.nlm.nih.gov/pubmed/26629689 http://dx.doi.org/10.1371/journal.pone.0144058

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