microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine production and neurotransmitter release following brain injury. Levels of the P2X7R are increased in experimental and human epilepsy but the mechanisms controlling P2X7R expression remain poorly understood. Here we i...

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Detalles Bibliográficos
Autores principales: Jimenez-Mateos, Eva M., Arribas-Blazquez, Marina, Sanz-Rodriguez, Amaya, Concannon, Caoimhin, Olivos-Ore, Luis A., Reschke, Cristina R., Mooney, Claire M., Mooney, Catherine, Lugara, Eleonora, Morgan, James, Langa, Elena, Jimenez-Pacheco, Alba, Silva, Luiz Fernando Almeida, Mesuret, Guillaume, Boison, Detlev, Miras-Portugal, M. Teresa, Letavic, Michael, Artalejo, Antonio R., Bhattacharya, Anindya, Diaz-Hernandez, Miguel, Henshall, David C., Engel, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668358/
https://www.ncbi.nlm.nih.gov/pubmed/26631939
http://dx.doi.org/10.1038/srep17486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668358/
https://www.ncbi.nlm.nih.gov/pubmed/26631939
http://dx.doi.org/10.1038/srep17486

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