Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system

Rapid identification of residues that influence antibody expression and thermostability is often needed to move promising therapeutics into the clinic. To establish a method that can assess small expression differences, we developed a Bacterial Antibody Display (BAD) system that overcomes previous l...

Descripción completa

Detalles Bibliográficos
Autores principales: Lombana, T. Noelle, Dillon, Michael, Bevers III, Jack, Spiess, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668361/
https://www.ncbi.nlm.nih.gov/pubmed/26631978
http://dx.doi.org/10.1038/srep17488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668361/
https://www.ncbi.nlm.nih.gov/pubmed/26631978
http://dx.doi.org/10.1038/srep17488

Ejemplares similares