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Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system
Rapid identification of residues that influence antibody expression and thermostability is often needed to move promising therapeutics into the clinic. To establish a method that can assess small expression differences, we developed a Bacterial Antibody Display (BAD) system that overcomes previous l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668361/ https://www.ncbi.nlm.nih.gov/pubmed/26631978 http://dx.doi.org/10.1038/srep17488 |