Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction

Rare individuals homozygous for a naturally-occurring 32 base pair deletion in the CCR5 gene (CCR5∆32/∆32) are resistant to infection by CCR5-using (“R5”) HIV-1 strains but remain susceptible to less common CXCR4-using (“X4”) strains. The evolutionary dynamics of X4 infections however, remain incomp...

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Detalles Bibliográficos
Autores principales: Le, Anh Q., Taylor, Jeremy, Dong, Winnie, McCloskey, Rosemary, Woods, Conan, Danroth, Ryan, Hayashi, Kanna, Milloy, M.-J., Poon, Art F. Y., Brumme, Zabrina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668558/
https://www.ncbi.nlm.nih.gov/pubmed/26631642
http://dx.doi.org/10.1038/srep17607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668558/
https://www.ncbi.nlm.nih.gov/pubmed/26631642
http://dx.doi.org/10.1038/srep17607

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