Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells

BACKGROUND: Mutations in myosin chaperones Unc45b and Hsp90aa1.1 as well as in the Unc45b-binding protein Smyd1b impair formation of myofibrils in skeletal muscle and lead to the accumulation of misfolded myosin. The concomitant transcriptional response involves up-regulation of the three genes enco...

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Detalles Bibliográficos
Autores principales: Etard, Christelle, Armant, Olivier, Roostalu, Urmas, Gourain, Victor, Ferg, Marco, Strähle, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668643/
https://www.ncbi.nlm.nih.gov/pubmed/26631063
http://dx.doi.org/10.1186/s13059-015-0825-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668643/
https://www.ncbi.nlm.nih.gov/pubmed/26631063
http://dx.doi.org/10.1186/s13059-015-0825-8

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