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Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells
BACKGROUND: Mutations in myosin chaperones Unc45b and Hsp90aa1.1 as well as in the Unc45b-binding protein Smyd1b impair formation of myofibrils in skeletal muscle and lead to the accumulation of misfolded myosin. The concomitant transcriptional response involves up-regulation of the three genes enco...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668643/ https://www.ncbi.nlm.nih.gov/pubmed/26631063 http://dx.doi.org/10.1186/s13059-015-0825-8 |