The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test

INTRODUCTION: Borago officinalis flower (borage) is a known sedative in herbal medicine; the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. METHODS: Fifty-six adult male albino Wistar rats were randomly divided into se...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahraki, Mohammad Reza, Ahmadimoghadm, Mahdieh, Shahraki, Ahmad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668875/
https://www.ncbi.nlm.nih.gov/pubmed/26649166
_version_ 1782404035417997312
author Shahraki, Mohammad Reza
Ahmadimoghadm, Mahdieh
Shahraki, Ahmad Reza
author_facet Shahraki, Mohammad Reza
Ahmadimoghadm, Mahdieh
Shahraki, Ahmad Reza
author_sort Shahraki, Mohammad Reza
collection PubMed
description INTRODUCTION: Borago officinalis flower (borage) is a known sedative in herbal medicine; the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. METHODS: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E, and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test. A biphasic pain was induced by injection of formalin 1%. The obtained data were analyzed by SPSS software ver. 17 employing statistical tests of Kruskal-Wallis and Mann-Whitney. The results were expressed as mean±SD. Statistical differences were considered significant at P<0.05. RESULTS: The results revealed that the acute and chronic pain behavior score in test groups of D, E, F, and G significantly decreased compared to groups A and B, but this score did not show any difference compared to group C. Moreover, chronic pain behavior score in group G was significantly lower than all other groups. DISCUSSION: The results indicated that Borago officinalis hydroalcoholic extract affects the acute and chronic pain behavior response in formaline test male rats.
format Online
Article
Text
id pubmed-4668875
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Iranian Neuroscience Society
record_format MEDLINE/PubMed
spelling pubmed-46688752015-12-08 The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test Shahraki, Mohammad Reza Ahmadimoghadm, Mahdieh Shahraki, Ahmad Reza Basic Clin Neurosci Research Papers INTRODUCTION: Borago officinalis flower (borage) is a known sedative in herbal medicine; the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. METHODS: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E, and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test. A biphasic pain was induced by injection of formalin 1%. The obtained data were analyzed by SPSS software ver. 17 employing statistical tests of Kruskal-Wallis and Mann-Whitney. The results were expressed as mean±SD. Statistical differences were considered significant at P<0.05. RESULTS: The results revealed that the acute and chronic pain behavior score in test groups of D, E, F, and G significantly decreased compared to groups A and B, but this score did not show any difference compared to group C. Moreover, chronic pain behavior score in group G was significantly lower than all other groups. DISCUSSION: The results indicated that Borago officinalis hydroalcoholic extract affects the acute and chronic pain behavior response in formaline test male rats. Iranian Neuroscience Society 2015-10 /pmc/articles/PMC4668875/ /pubmed/26649166 Text en Copyright© 2015 Iranian Neuroscience Society This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Research Papers
Shahraki, Mohammad Reza
Ahmadimoghadm, Mahdieh
Shahraki, Ahmad Reza
The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title_full The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title_fullStr The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title_full_unstemmed The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title_short The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
title_sort antinociceptive effects of hydroalcoholic extract of borago officinalis flower in male rats using formalin test
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668875/
https://www.ncbi.nlm.nih.gov/pubmed/26649166
work_keys_str_mv AT shahrakimohammadreza theantinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest
AT ahmadimoghadmmahdieh theantinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest
AT shahrakiahmadreza theantinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest
AT shahrakimohammadreza antinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest
AT ahmadimoghadmmahdieh antinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest
AT shahrakiahmadreza antinociceptiveeffectsofhydroalcoholicextractofboragoofficinalisflowerinmaleratsusingformalintest