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Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice

Alzheimer's disease (AD) is heterogeneous and multifactorial neurological disorder; and the risk factors of AD still remain elusive. Recent studies have highlighted the role of vascular factors in promoting the progression of AD and have suggested that ischemic events increase the incidence of...

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Detalles Bibliográficos
Autores principales: Lu, Lin, Guo, Lan, Gauba, Esha, Tian, Jing, Wang, Lu, Tandon, Neha, Shankar, Malini, Beck, Simon J., Du, Yifeng, Du, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669173/
https://www.ncbi.nlm.nih.gov/pubmed/26632816
http://dx.doi.org/10.1371/journal.pone.0144068