Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis

BACKGROUND: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk factor for atopic dermatitis (AD) and are known to cause an epidermal barrier defect. The nature of this barrier defect is not fully understood. Patients with AD with FLG LOF mutations are known to ha...

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Detalles Bibliográficos
Autores principales: Riethmuller, Christoph, McAleer, Maeve A., Koppes, Sjors A., Abdayem, Rawad, Franz, Jonas, Haftek, Marek, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Irvine, Alan D., Kezic, Sanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2015
Materias:
Atopic Dermatitis and Skin Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669308/
https://www.ncbi.nlm.nih.gov/pubmed/26071937
http://dx.doi.org/10.1016/j.jaci.2015.04.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669308/
https://www.ncbi.nlm.nih.gov/pubmed/26071937
http://dx.doi.org/10.1016/j.jaci.2015.04.042

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