Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

Respiratory complex II (CII, succinate dehydrogenase, SDH) inhibition can induce cell death, but the mechanistic details need clarification. To elucidate the role of reactive oxygen species (ROS) formation upon the ubiquinone-binding (Q(p)) site blockade, we substituted CII subunit C (SDHC) residues...

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Detalles Bibliográficos
Autores principales: Kluckova, K, Sticha, M, Cerny, J, Mracek, T, Dong, L, Drahota, Z, Gottlieb, E, Neuzil, J, Rohlena, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669690/
https://www.ncbi.nlm.nih.gov/pubmed/25950479
http://dx.doi.org/10.1038/cddis.2015.110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669690/
https://www.ncbi.nlm.nih.gov/pubmed/25950479
http://dx.doi.org/10.1038/cddis.2015.110

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