Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

One prerequisite that radiotherapy (RT) and chemotherapy (CT) result in anti-tumor immune responses is triggering of immunogenic cell death forms such as necroptosis. The latter is inducible by inhibition of apoptosis with the pan-caspase inhibitor zVAD-fmk. The design of multimodal therapies that o...

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Detalles Bibliográficos
Autores principales: Werthmöller, N, Frey, B, Wunderlich, R, Fietkau, R, Gaipl, U S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669707/
https://www.ncbi.nlm.nih.gov/pubmed/25973681
http://dx.doi.org/10.1038/cddis.2015.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669707/
https://www.ncbi.nlm.nih.gov/pubmed/25973681
http://dx.doi.org/10.1038/cddis.2015.129

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