Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization

The marine natural product fascaplysin (1) is a potent Cdk4 (cyclin-dependent kinase 4)-specific inhibitor, but is toxic to all cell types possibly because of its DNA-intercalating properties. Through the design and synthesis of numerous fascaplysin analogues, we intended to identify inhibitors of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahale, S, Bharate, S B, Manda, S, Joshi, P, Jenkins, P R, Vishwakarma, R A, Chaudhuri, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669722/
https://www.ncbi.nlm.nih.gov/pubmed/25950473
http://dx.doi.org/10.1038/cddis.2015.96

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669722/
https://www.ncbi.nlm.nih.gov/pubmed/25950473
http://dx.doi.org/10.1038/cddis.2015.96

Ejemplares similares