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Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization

The marine natural product fascaplysin (1) is a potent Cdk4 (cyclin-dependent kinase 4)-specific inhibitor, but is toxic to all cell types possibly because of its DNA-intercalating properties. Through the design and synthesis of numerous fascaplysin analogues, we intended to identify inhibitors of c...

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Detalles Bibliográficos
Autores principales:	Mahale, S, Bharate, S B, Manda, S, Joshi, P, Jenkins, P R, Vishwakarma, R A, Chaudhuri, B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669722/ https://www.ncbi.nlm.nih.gov/pubmed/25950473 http://dx.doi.org/10.1038/cddis.2015.96

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