Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

Changes of cellular metabolism are an integral property of the malignant potential of most cancer cells. Already in the 1930s, Otto Warburg observed that tumor cells preferably utilize glycolysis and lactate fermentation for energy production, rather than the mitochondrial oxidative phosphorylation...

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Detalles Bibliográficos
Autores principales: Nilsson, H, Lindgren, D, Mandahl Forsberg, A, Mulder, H, Axelson, H, Johansson, M E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669744/
https://www.ncbi.nlm.nih.gov/pubmed/25569102
http://dx.doi.org/10.1038/cddis.2014.545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669744/
https://www.ncbi.nlm.nih.gov/pubmed/25569102
http://dx.doi.org/10.1038/cddis.2014.545

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