DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

DRAM1 (DNA damage-regulated autophagy modulator 1) is a TP53 target gene that modulates autophagy and apoptosis. We previously found that DRAM1 increased autophagy flux by promoting lysosomal acidification and protease activation. However, the molecular mechanisms by which DRAM1 regulates apoptosis...

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Detalles Bibliográficos
Autores principales: Guan, J-J, Zhang, X-D, Sun, W, Qi, L, Wu, J-C, Qin, Z-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669745/
https://www.ncbi.nlm.nih.gov/pubmed/25633293
http://dx.doi.org/10.1038/cddis.2014.546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669745/
https://www.ncbi.nlm.nih.gov/pubmed/25633293
http://dx.doi.org/10.1038/cddis.2014.546

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