A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability

Prolonged culture of embryonic stem cells (ESCs) leads them to adopt embryonal carcinoma cell features, creating enormous dangers for their further application. The mechanism involved in ESC stability has not, however, been extensively studied. We previously reported that SMAD family member 3 (Smad3...

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Detalles Bibliográficos
Autores principales: Li, P, Ma, X, Adams, I R, Yuan, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669749/
https://www.ncbi.nlm.nih.gov/pubmed/25569105
http://dx.doi.org/10.1038/cddis.2014.551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669749/
https://www.ncbi.nlm.nih.gov/pubmed/25569105
http://dx.doi.org/10.1038/cddis.2014.551

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