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A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability
Prolonged culture of embryonic stem cells (ESCs) leads them to adopt embryonal carcinoma cell features, creating enormous dangers for their further application. The mechanism involved in ESC stability has not, however, been extensively studied. We previously reported that SMAD family member 3 (Smad3...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669749/ https://www.ncbi.nlm.nih.gov/pubmed/25569105 http://dx.doi.org/10.1038/cddis.2014.551 |