Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage

Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphoryl...

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Detalles Bibliográficos
Autores principales: Tong, Y, Ying, H, Liu, R, Li, L, Bergholz, J, Xiao, Z-X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669794/
https://www.ncbi.nlm.nih.gov/pubmed/25675300
http://dx.doi.org/10.1038/cddis.2015.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669794/
https://www.ncbi.nlm.nih.gov/pubmed/25675300
http://dx.doi.org/10.1038/cddis.2015.3

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