Cargando…

Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice

Mechanism of radiosensitivity of normal tissues, a key factor in determining the toxic side effects of cancer radiotherapy, is not fully understood. We recently demonstrated that deficiency of mitochondrial tumor suppressor, Fus1, increases radiosensitivity at the organismal, tissue and cellular lev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yazlovitskaya, E M, Voziyan, P A, Manavalan, T, Yarbrough, W G, Ivanova, A V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669799/ https://www.ncbi.nlm.nih.gov/pubmed/25695605 http://dx.doi.org/10.1038/cddis.2014.593

Ejemplares similares

A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1
por: Yazlovitskaya, E M, et al.
Publicado: (2013)

Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity
por: Uzhachenko, Roman, et al.
Publicado: (2015)

Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments
por: Coronas-Samano, Guillermo, et al.
Publicado: (2016)

Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
por: Ivanova, Alla V, et al.
Publicado: (2009)

Abl kinase-mediated FUS Tyr526 phosphorylation alters nucleocytoplasmic FUS localization in FTLD-FUS
por: Motaln, Helena, et al.
Publicado: (2023)

The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity
por: Brunet, Marie A, et al.
Publicado: (2020)

Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
por: Tan, Winston J. T., et al.
Publicado: (2023)

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress
por: Martinez-Macias, Maria Isabel, et al.
Publicado: (2019)

Mitochondrial Fus1/Tusc2 and cellular Ca2(+) homeostasis: tumor suppressor, anti-inflammatory and anti-aging implications
por: Uzhachenko, Roman, et al.
Publicado: (2022)

A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice
por: Chaprov, Kirill, et al.
Publicado: (2021)

A loss of FUS/TLS function leads to impaired cellular proliferation
por: Ward, C L, et al.
Publicado: (2014)

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS
por: Sama, Reddy Ranjith Kumar, et al.
Publicado: (2014)

Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization
por: Maier, Patrick, et al.
Publicado: (2016)

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration
por: Kishino, Yuya, et al.
Publicado: (2022)

Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature
por: Schleicher, Stephen M., et al.
Publicado: (2011)

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS
por: An, Haiyan, et al.
Publicado: (2020)

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
por: Naumann, Marcel, et al.
Publicado: (2018)

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
por: Vance, Caroline, et al.
Publicado: (2013)

Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity
por: Shestovskaya, Maria V., et al.
Publicado: (2023)

Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice
por: Mirra, Alessia, et al.
Publicado: (2017)

ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation
por: King, Andrew, et al.
Publicado: (2015)

Early Alterations in Structural and Functional Properties in the Neuromuscular Junctions of Mutant FUS Mice
por: Mukhamedyarov, Marat A., et al.
Publicado: (2023)

High replication stress and limited Rad51-mediated DNA repair capacity, but not oxidative stress, underlie oligodendrocyte precursor cell radiosensitivity
por: Berger, N Daniel, et al.
Publicado: (2022)

Publisher Correction: Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice
por: Mirra, Alessia, et al.
Publicado: (2018)

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases
por: Choi, Sangyong, et al.
Publicado: (2018)

Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors
por: Schrank, Travis P., et al.
Publicado: (2023)

ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
por: Zhou, Yueqin, et al.
Publicado: (2013)

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions
por: Farrawell, Natalie E., et al.
Publicado: (2015)

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy
por: Marrone, Lara, et al.
Publicado: (2018)

Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.
por: Sheldon, P. W., et al.
Publicado: (1975)

The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro
por: Meyer, Till Jasper, et al.
Publicado: (2019)

Antioxidant responses and cellular adjustments to oxidative stress
por: Espinosa-Diez, Cristina, et al.
Publicado: (2015)

The Role of Catechins in Cellular Responses to Oxidative Stress
por: Bernatoniene, Jurga, et al.
Publicado: (2018)

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
por: Norris, Adriana C., et al.
Publicado: (2023)

The Influence of MicroRNA-31 on Oxidative Stress and Radiosensitivity in Pancreatic Ductal Adenocarcinoma
por: McGrath, Jason, et al.
Publicado: (2022)

Intrinsic Radiosensitivity and Cellular Characterization of 27 Canine Cancer Cell Lines
por: Maeda, Junko, et al.
Publicado: (2016)

PLK-1 Interacting Checkpoint Helicase, PICH, Mediates Cellular Oxidative Stress Response
por: Dutta, Anindita, et al.
Publicado: (2022)

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity
por: An, Haiyan, et al.
Publicado: (2022)

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm
por: Shelkovnikova, Tatyana A, et al.
Publicado: (2013)

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations
por: Finelli, Mattéa J., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_umm56ukj6kurs0hd0vj4vsoa3r