Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons

The glial cell line-derived neurotrophic factor (GDNF) has an important role in neuronal survival through binding to the GFRα1 (GDNF family receptor alpha-1) receptor and activation of the receptor tyrosine kinase Ret. Transient brain ischemia alters the expression of the GDNF signaling machinery bu...

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Detalles Bibliográficos
Autores principales: Curcio, M, Salazar, I L, Inácio, A R, Duarte, E P, Canzoniero, L M T, Duarte, C B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669807/
https://www.ncbi.nlm.nih.gov/pubmed/25675305
http://dx.doi.org/10.1038/cddis.2014.578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669807/
https://www.ncbi.nlm.nih.gov/pubmed/25675305
http://dx.doi.org/10.1038/cddis.2014.578

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