Cargando…
p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53
Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained a mystery whether p53 is active in this cell type. We show that a significant part of p53 is localised in the nucleus of murine embryonic stem cells and that the majority of this nuclear p53 is bound to DNA....
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669809/ https://www.ncbi.nlm.nih.gov/pubmed/25719246 http://dx.doi.org/10.1038/cddis.2015.33 |